Immune Subtyping in Latent Tuberculosis

Latent tuberculosis infection (LTBI) poses a major roadblock in the global effort to eradicate (TB). A deep understanding of host responses involved establishment and maintenance TB latency is required propel development sensitive methods detect treat LTBI. Given that LTBI individuals are typically asymptomatic, it challenging differentiate latently infected from uninfected individuals. contributor this problem no clear pattern response linked with LTBI, as molecular correlates latent have been hard identify. In study, we analyzed perturbations compared particularly heterogeneity such response, across cohorts. For this, constructed individualized genome-wide networks informed by blood transcriptomes for 136 cases used network mining algorithm identify top-ranked subnetworks each case. Our analysis indicates despite high gene expression profiles among samples, patterns perturbation found immune pathways, leading grouping samples into 4 different immune-subtypes. results suggest associated tuberculosis.